TNRC6B

TNRC6B (Trinucleotide Repeat Containing 6B) is a Protein Coding gene. Among its related pathways are RET signaling and Innate Immune System. Gene Ontology (GO) annotations related to TNRC6B include nucleotide binding. An important paralog of TNRC6B is TNRC6A.

trinucleotide repeat containing 6B

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837).
Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837).
As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923).

Biological Process gene silencing by RNA Source:UniProtKB1 Publication
Biological Process miRNA-mediated gene silencing Source:GO_Central1 Publication
Biological Process miRNA-mediated gene silencing by inhibition of translation Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source:UniProtKB1 Publication

Cytoplasm, P-body
Mammalian P-bodies are also known as GW bodies (GWBs).

Global developmental delay with speech and behavioral abnormalities (GDSBA):
An autosomal dominant disorder manifesting in infancy or early childhood. It is characterized by mildly delayed fine and motor skills, mildly impaired intellectual development, speech and language delay, and variable behavioral abnormalities, mostly autism and attention-deficit hyperactivity disorder. Additional non-specific features include facial dysmorphism, myopia or strabismus, and skeletal defects.