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Mouse Anti-TNRC6B Recombinant Antibody (3G11) (CBMAB-A9408-LY)

The product is antibody recognizes TNRC6B. The antibody 3G11 immunoassay techniques such as: WB, ELISA.
See all TNRC6B antibodies
Published Data
Fig. 1 Western blot of GW182 family members (TNRC6A–C) after siRNA-mediated knockdown.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3G11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TNRC6B (NP_055903, 253 a.a. ~ 352 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
trinucleotide repeat containing 6B
Entrez Gene ID
23112
UniProt ID
Q9UPQ9
Alternative Names
KIAA1093
Function
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837).
Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837).
As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923).
Biological Process
Biological Process gene silencing by RNA Source:UniProtKB1 Publication
Biological Process miRNA-mediated gene silencing Source:GO_Central1 Publication
Biological Process miRNA-mediated gene silencing by inhibition of translation Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, P-body
Mammalian P-bodies are also known as GW bodies (GWBs).
Involvement in disease
Global developmental delay with speech and behavioral abnormalities (GDSBA):
An autosomal dominant disorder manifesting in infancy or early childhood. It is characterized by mildly delayed fine and motor skills, mildly impaired intellectual development, speech and language delay, and variable behavioral abnormalities, mostly autism and attention-deficit hyperactivity disorder. Additional non-specific features include facial dysmorphism, myopia or strabismus, and skeletal defects.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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