TOP3B

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Full Name
TOP3B Gene(Protein Coding) DNA Topoisomerase III Beta
Function
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
Possesses negatively supercoiled DNA relaxing activity.
Biological Process
Biological Process chromosome segregation Source:Ensembl
Biological Process DNA topological change Source:GO_Central1 Publication
Cellular Location
condensed chromosome
DNA topoisomerase III-beta-TDRD3 complex
nucleus
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Anti-TOP3B antibodies

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Mouse Anti-TOP3B Recombinant Antibody (CBYJT-4217) (CBMAB-T3681-YJ)

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Target: TOP3B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-4217
Application*: IF, E, WB
Datasheet SDS

TOP3B Matched Antibody Pair (1255) (APMAB-1255LY)

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Target: TOP3B
Specificity: Human
Datasheet SDS

Mouse Anti-TOP3B Recombinant Antibody (4H7) (CBMAB-A9430-LY)

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Target: TOP3B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4H7
Application*: WB, E
Datasheet SDS

Mouse Anti-TOP3B Recombinant Antibody (4F11) (CBMAB-A9429-LY)

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Target: TOP3B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F11
Application*: WB, E
Datasheet SDS

Mouse Anti-TOP3B Recombinant Antibody (2G2) (CBMAB-A9428-LY)

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Target: TOP3B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G2
Application*: WB, E
Datasheet SDS

Mouse Anti-TOP3B Recombinant Antibody (1H8) (CBMAB-A9427-LY)

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Target: TOP3B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H8
Application*: WB, E
Datasheet SDS

Mouse Anti-TOP3B Recombinant Antibody (1H4) (CBMAB-A9426-LY)

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Target: TOP3B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1H4
Application*: WB, E
Datasheet SDS

Mouse Anti-TOP3B Recombinant Antibody (CBYJT-4216) (CBMAB-T3680-YJ)

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Target: TOP3B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-4216
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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