TPSG1
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. TPSG1 differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Full Name
Tryptase Gamma 1
Biological Process
Biological Process proteolysis Source:GO_Central1 Publication
Cellular Location
Membrane
Topology
Helical: 284-304
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Anti-TPSG1 antibodies
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Target: TPSG1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4428
Application*: WB
Target: TPSG1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4427
Application*: WB
Target: TPSG1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4426
Application*: WB
Target: TPSG1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4425
Application*: WB
Target: TPSG1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4424
Application*: WB, IF, F
Target: TPSG1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4423
Application*: WB, IP
Target: TPSG1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4422
Application*: WB, F, IH, P
Target: TPSG1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4421
Application*: WB, F
Target: TPSG1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4420
Application*: WB, F
Target: TPSG1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Cat, Human, Monkey, Rat
Clone: CBFYM-3165
Application*: E, IF, IH, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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