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TRA2B

TRA2B is a nuclear protein which plays a role as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression.

Full Name

Transformer 2 Beta Homolog

Function

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.

Biological Process

Biological Process cellular response to glucose stimulus Source:CAFA1 Publication
Biological Process cerebral cortex regionalization Source:Ensembl
Biological Process embryonic brain development Source:Ensembl
Biological Process mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process positive regulation of mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process regulation of alternative mRNA splicing, via spliceosome Source:UniProtKB2 Publications
Biological Process regulation of RNA splicing Source:UniProtKB1 Publication
Biological Process RNA splicing, via transesterification reactions Source:UniProtKB1 Publication

Cellular Location

Nucleus

PTM

Phosphorylated in the RS domains.
Dimethylation at Arg-241 is probably asymmetric.

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Anti-TRA2B antibodies

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Mouse Anti-TRA2B Recombinant Antibody (7A1) (CBMAB-A8032-LY)

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Target: TRA2B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 7A1

Application*: WB, E

Mouse Anti-TRA2B Recombinant Antibody (CBYJT-4473) (CBMAB-T3976-YJ)

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Target: TRA2B

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Clone: CBYJT-4473

Application*: WB, IP, IF, E

Mouse Anti-TRA2B Recombinant Antibody (CBYJT-4472) (CBMAB-T3975-YJ)

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Target: TRA2B

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Clone: CBYJT-4472

Application*: WB, IP, IF, P, E

Mouse Anti-TRA2B Recombinant Antibody (CBYJT-4471) (CBMAB-T3974-YJ)

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Target: TRA2B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4471

Application*: E, WB

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Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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