Mouse Anti-TRA2B Recombinant Antibody (CBYJT-4472) (CBMAB-T3975-YJ)

Name: Mouse Anti-TRA2B Recombinant Antibody (CBYJT-4472)
SKU: CBMAB-T3975-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4472

Application

WB, IP, IF, IHC-P, ELISA

Immunogen

Specific for an epitope mapping between amino acids 19-36 near the N-terminus of Tra-2β of human origin

Specificity

Human, Rat, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 19-36

More Infomation

Target

Full Name

Transformer 2 Beta Homolog

Introduction

TRA2B is a nuclear protein which plays a role as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression.

Entrez Gene ID

Human	6434
Mouse	20462
Rat	117259

UniProt ID

Human	P62995
Mouse	P62996
Rat	P62997

Alternative Names

Transformer 2 Beta Homolog; Splicing Factor, Arginine/Serine-Rich 10 (Transformer 2 Homolog, Drosophila); Protein Phosphatase 1, Regulatory Subunit 156; Transformer-2 Protein Homolog B; TRA-2 Beta; Htra2-Beta; TRA2-BETA; SFRS10

Function

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.

Biological Process

Biological Process cellular response to glucose stimulus Source:CAFA1 Publication
Biological Process cerebral cortex regionalization Source:Ensembl
Biological Process embryonic brain development Source:Ensembl
Biological Process mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process positive regulation of mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process regulation of alternative mRNA splicing, via spliceosome Source:UniProtKB2 Publications
Biological Process regulation of RNA splicing Source:UniProtKB1 Publication
Biological Process RNA splicing, via transesterification reactions Source:UniProtKB1 Publication

Cellular Location

Nucleus

PTM

Phosphorylated in the RS domains.
Dimethylation at Arg-241 is probably asymmetric.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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