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Mouse Anti-TRA2B Recombinant Antibody (CBYJT-4471) (CBMAB-T3974-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRA2B (Transformer 2 Beta Homolog). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TRA2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4471
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa120-199 from SFRS10 (NP_004584) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 120-199

Target

Full Name
Transformer 2 Beta Homolog
Introduction
TRA2B is a nuclear protein which plays a role as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression.
Entrez Gene ID
6434
UniProt ID
P62995
Alternative Names
Transformer 2 Beta Homolog; Splicing Factor, Arginine/Serine-Rich 10 (Transformer 2 Homolog, Drosophila); Protein Phosphatase 1, Regulatory Subunit 156; Transformer-2 Protein Homolog B; TRA-2 Beta; Htra2-Beta; TRA2-BETA; SFRS10
Function
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
Biological Process
Biological Process cellular response to glucose stimulus Source:CAFA1 Publication
Biological Process cerebral cortex regionalization Source:Ensembl
Biological Process embryonic brain development Source:Ensembl
Biological Process mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process positive regulation of mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process regulation of alternative mRNA splicing, via spliceosome Source:UniProtKB2 Publications
Biological Process regulation of RNA splicing Source:UniProtKB1 Publication
Biological Process RNA splicing, via transesterification reactions Source:UniProtKB1 Publication
Cellular Location
Nucleus
PTM
Phosphorylated in the RS domains.
Dimethylation at Arg-241 is probably asymmetric.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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