TREM1
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Full Name
TREM1 Gene(Protein Coding) Triggering Receptor Expressed On Myeloid Cells 1
Function
Isoform 1
Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102).
Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:25595774, PubMed:17568691, PubMed:29568119).
In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:21659545, PubMed:14656437).
This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17568691, PubMed:17098818).
By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:21393102, PubMed:11323674).
Isoform 2
Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its lignad.
Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102).
Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:25595774, PubMed:17568691, PubMed:29568119).
In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:21659545, PubMed:14656437).
This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17568691, PubMed:17098818).
By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:21393102, PubMed:11323674).
Isoform 2
Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its lignad.
Biological Process
Biological Process acute inflammatory response Source:InterPro
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process humoral immune response Source:ProtInc1 Publication
Biological Process innate immune response Source:UniProtKB-KW
Biological Process intracellular signal transduction Source:ProtInc1 Publication
Biological Process neutrophil chemotaxis Source:GO_Central1 Publication
Biological Process neutrophil-mediated killing of gram-negative bacterium Source:GO_Central1 Publication
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process humoral immune response Source:ProtInc1 Publication
Biological Process innate immune response Source:UniProtKB-KW
Biological Process intracellular signal transduction Source:ProtInc1 Publication
Biological Process neutrophil chemotaxis Source:GO_Central1 Publication
Biological Process neutrophil-mediated killing of gram-negative bacterium Source:GO_Central1 Publication
Cellular Location
Isoform 1
Cell membrane
Recruited to lipid rafts when activated.
Isoform 2
Secreted
Cell membrane
Recruited to lipid rafts when activated.
Isoform 2
Secreted
Topology
Extracellular: 21-205
Helical: 206-226
Cytoplasmic: 227-234
Helical: 206-226
Cytoplasmic: 227-234
PTM
Glycosylated.
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Anti-TREM1 antibodies
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CompareTarget: TREM1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: TR3MBL1
Application*: F
Target: TREM1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-202
Tag: His Tag
Target: TREM1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-200
Tag: His & hFc Tag
Target: TREM1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-200
Tag: His Tag
Target: TREM1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-200
Tag: His Tag
Target: TREM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4740
Application*: F
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Monkey
Clone: CBT3119
Application*: WB, F
Target: TREM1
Specificity: Human
Target: TREM1
Specificity: Human
Target: TREM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBHb076
Application*: FC, FuncS, IF, WB
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb320
Application*: Immuno assays
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb288
Application*: FC, FuncS, Immuno assays, WB
Target: TREM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D7D6I
Application*: F
Target: TREM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F5
Application*: WB, E
Target: TREM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2E2
Application*: WB, E
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 15G7
Application*: IA
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0189
Application*: F, FN, IA, WB
Target: TREM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYA-0049
Application*: F, FN, IF, WB
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3745
Application*: IA
Target: TREM1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0748
Application*: F
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2030
Application*: F
Target: Trem1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: L5-B8
Application*: WB, F, IC, IF, FN
Target: Trem1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 3C66
Application*: WB, IH, FN
Target: Trem1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-4606
Application*: WB, F, AG, IC, MC
Target: Trem1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-4605
Application*: F, IF, IH, WB
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4604
Application*: IA, IC, IF, WB, FN
Target: TREM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4603
Application*: E, WB
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4602
Application*: WB, P
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4601
Application*: F, A
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4599
Application*: F, FN, IA, WB
Target: TREM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-4598
Application*: E, WB
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4597
Application*: F, AG, MC
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4596
Application*: F, WB
Target: TREM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4595
Application*: ED
Target: TREM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4594
Application*: EC
Target: TREM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3208
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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