Human Recombinant TREM1 protein, His & hFc Tag (V2LY-0526-LY7365)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102).
Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:25595774, PubMed:17568691, PubMed:29568119).
In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:21659545, PubMed:14656437).
This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17568691, PubMed:17098818).
By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:21393102, PubMed:11323674).
Isoform 2
Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its lignad.
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process humoral immune response Source:ProtInc1 Publication
Biological Process innate immune response Source:UniProtKB-KW
Biological Process intracellular signal transduction Source:ProtInc1 Publication
Biological Process neutrophil chemotaxis Source:GO_Central1 Publication
Biological Process neutrophil-mediated killing of gram-negative bacterium Source:GO_Central1 Publication
Cell membrane
Recruited to lipid rafts when activated.
Isoform 2
Secreted
Helical: 206-226
Cytoplasmic: 227-234
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
TREM1 Matched Antibody Pair (1269) (CAT#: APMAB-1269LY)
Human Recombinant TREM1 protein, ECD, His Tag (CAT#: V2LY-0526-LY7363)
Human Recombinant TREM1 protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY7364)
Mouse Recombinant TREM1 protein, ECD, His Tag (CAT#: V2LY-0526-LY9016)
Antibody Pairs
TREM1 Matched Antibody Pair (1269) (CAT#: APMAB-1269LY)
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Human Anti-TREM1 Recombinant Antibody (CBXC-0748) (CAT#: CBMAB-C1862-CQ)
Mouse Anti-TREM1 Recombinant Antibody (CBYJT-4602) (CAT#: CBMAB-T4124-YJ)
Mouse Anti-TREM1 Recombinant Antibody (CBT3119) (CAT#: V2LY-0625-LY1167)
Rabbit Anti-TREM1 Recombinant Antibody (D7D6I) (CAT#: CBMAB-CP2853-LY)
Rat Anti-Trem1 Recombinant Antibody (CBYJT-4606) (CAT#: CBMAB-T4130-YJ)
Mouse Anti-TREM1 Recombinant Antibody (CBFYC-3208) (CAT#: CBMAB-C3285-FY)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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