TRIM35

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq]

Full Name

tripartite motif-containing 35

Function

E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via DDX58/RIG-I signaling pathway (PubMed:32562145).
Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145).
Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537).
Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439).

Biological Process

Biological Process apoptotic process Source:UniProtKB-KW
Biological Process innate immune response Source:UniProtKB1 Publication
Biological Process negative regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process suppression of viral release by host Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Nucleus
Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity).