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Mouse Anti-TRIM35 Recombinant Antibody (CBYJT-4757) (CBMAB-T4298-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM35 (Tripartite Motif Containing 35). The antibody can be used for immunoassay techniques, such as ELISA, IHC.
See all TRIM35 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4757
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC

Basic Information

Immunogen
Partial recombinant protein corresponding to a portion of amino acids within aa394-494 of human TRIM35 with GST tag (NP_055881). MW of GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 394-494

Target

Full Name
tripartite motif-containing 35
Introduction
TRIM35 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of it has not been identified.
Entrez Gene ID
23087
UniProt ID
Q9UPQ4
Alternative Names
Tripartite Motif Containing 35; Hemopoietic Lineage Switch Protein 5; HLS5; Tripartite Motif-Containing Protein 35; Tripartite Motif-Containing 35; KIAA1098; MAIR
Function
E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via DDX58/RIG-I signaling pathway (PubMed:32562145).
Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145).
Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537).
Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439).
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process innate immune response Source:UniProtKB1 Publication
Biological Process negative regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process suppression of viral release by host Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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