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Mouse Anti-TRIM35 Recombinant Antibody (CBYJT-4758) (CBMAB-T4299-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4758
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tripartite motif-containing 35
Introduction
TRIM35 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of it has not been identified.
Entrez Gene ID
23087
UniProt ID
Q9UPQ4
Alternative Names
Tripartite Motif Containing 35; Hemopoietic Lineage Switch Protein 5; HLS5; Tripartite Motif-Containing Protein 35; Tripartite Motif-Containing 35; KIAA1098; MAIR
Function
E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via DDX58/RIG-I signaling pathway (PubMed:32562145).
Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145).
Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537).
Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439).
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process innate immune response Source:UniProtKB1 Publication
Biological Process negative regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process suppression of viral release by host Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity).
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For research use only. Not intended for any clinical use.

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