TRPC4AP

TRPC4AP (Transient Receptor Potential Cation Channel Subfamily C Member 4 Associated Protein) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include phosphatase binding.

Full Name

TRPC4AP Transient Receptor Potential Cation Channel Subfamily C Member 4 Associated Protein

Function

Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control (PubMed:20551172, PubMed:29779948).
The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway (PubMed:20551172, PubMed:29779948).
The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948).
The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (PubMed:29779948).
Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity).
Involved in JNK activation via its interaction with TRAF2 (By similarity).
Also involved in elevation of endoplasmic reticulum Ca2+ storage reduction in response to CHRM1 (By similarity).

Biological Process

Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process hair follicle maturation Source:Ensembl
Biological Process protein ubiquitination Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process via the C-end degron rule pathway Source:UniProtKB1 Publication

Cellular Location

Cytoplasm, perinuclear region

PTM

Phosphorylated by GSK3B; phosphorylation is required for ubiquitination.
Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase containing SKP2, leading to its degradation (PubMed:26038816).
Phosphorylation by GSK3B is required for ubiquitination (PubMed:26038816).