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Mouse Anti-TRPC4AP Recombinant Antibody (CBYJT-4903) (CBMAB-T4450-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRPC4AP (Transient Receptor Potential Cation Channel Subfamily C Member 4 Associated Protein). The antibody can be used for immunoassay techniques, such as ELISA.
See all TRPC4AP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4903
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa341-452 from human TRPC4AP (NP_056453) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 341-452

Target

Full Name
TRPC4AP Transient Receptor Potential Cation Channel Subfamily C Member 4 Associated Protein
Introduction
TRPC4AP (Transient Receptor Potential Cation Channel Subfamily C Member 4 Associated Protein) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to TRPC4AP include phosphatase binding.
Entrez Gene ID
UniProt ID
Alternative Names
Transient Receptor Potential Cation Channel Subfamily C Member 4 Associated Protein; TNF-Receptor Ubiquitous Scaffolding/Signaling Protein; Protein Phosphatase 1, Regulatory Subunit 158; Trpc4-Associated Protein; C20orf188; TRRP4AP; Tumor Necrosis Factor Receptor-Associated Ubiquitous Scaffolding And Signaling Protein; Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein; Short Transient Receptor Potential Channel 4-Associated Protein
Function
Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control (PubMed:20551172, PubMed:29779948).
The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway (PubMed:20551172, PubMed:29779948).
The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948).
The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (PubMed:29779948).
Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity).
Involved in JNK activation via its interaction with TRAF2 (By similarity).
Also involved in elevation of endoplasmic reticulum Ca2+ storage reduction in response to CHRM1 (By similarity).
Biological Process
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process hair follicle maturation Source:Ensembl
Biological Process protein ubiquitination Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process via the C-end degron rule pathway Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, perinuclear region
PTM
Phosphorylated by GSK3B; phosphorylation is required for ubiquitination.
Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase containing SKP2, leading to its degradation (PubMed:26038816).
Phosphorylation by GSK3B is required for ubiquitination (PubMed:26038816).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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