Sign in or Register   Sign in or Register
  |  

Mouse Anti-TRPC4AP Recombinant Antibody (3G4) (CBMAB-A9549-LY)

The product is antibody recognizes TRPC4AP. The antibody 3G4 immunoassay techniques such as: sELISA, ELISA.
See all TRPC4AP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G4
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
TRPC4AP (NP_056453, 341 a.a. ~ 451 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TRPC4AP Transient Receptor Potential Cation Channel Subfamily C Member 4 Associated Protein
Entrez Gene ID
26133
UniProt ID
Q8TEL6
Alternative Names
C20orf188; TRRP4AP; TRUSS
Function
Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control (PubMed:20551172, PubMed:29779948).
The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway (PubMed:20551172, PubMed:29779948).
The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948).
The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (PubMed:29779948).
Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity).
Involved in JNK activation via its interaction with TRAF2 (By similarity).
Also involved in elevation of endoplasmic reticulum Ca2+ storage reduction in response to CHRM1 (By similarity).
Biological Process
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process hair follicle maturation Source:Ensembl
Biological Process protein ubiquitination Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process via the C-end degron rule pathway Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, perinuclear region
PTM
Phosphorylated by GSK3B; phosphorylation is required for ubiquitination.
Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase containing SKP2, leading to its degradation (PubMed:26038816).
Phosphorylation by GSK3B is required for ubiquitination (PubMed:26038816).
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TRPC4AP Recombinant Antibody (3G4)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare