TRPC6

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]

Full Name

TRPC6 Gene(Protein Coding) Transient Receptor Potential Cation Channel Subfamily C Member 6

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369).
Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346).
Seems not to be activated by intracellular calcium store depletion.

Biological Process

Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process cation transport Source:ProtInc1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process positive regulation of calcium ion transport Source:MGI1 Publication
Biological Process positive regulation of cytosolic calcium ion concentration Source:Ensembl
Biological Process positive regulation of ion transmembrane transporter activity Source:MGI1 Publication
Biological Process regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Biological Process single fertilization Source:GO_Central1 Publication

Cellular Location

Cell membrane

Involvement in disease

Focal segmental glomerulosclerosis 2 (FSGS2):
A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.

Topology

Cytoplasmic: 1-438
Helical: 439-459
Extracellular: 460-487
Helical: 488-508
Cytoplasmic: 509-521
Helical: 522-542
Extracellular: 543-592
Helical: 593-613
Cytoplasmic: 614-636
Helical: 637-657
Extracellular: 658-706
Helical: 707-727
Cytoplasmic: 728-931

PTM

Phosphorylated by FYN, leading to an increase of TRPC6 channel activity.