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Mouse Anti-TRPC6 Recombinant Antibody (3F2.H10.F2) (CBMAB-T4457-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRPC6 (Transient Receptor Potential Cation Channel Subfamily C Member 6). The antibody can be used for immunoassay techniques, such as WB, ELISA, IHC-P.
See all TRPC6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F2.H10.F2
Antibody Isotype
IgG1
Application
WB, ELISA, IHC-P

Basic Information

Immunogen
Synthetic peptide corresponding to a region near the C terminal of Human TRPC6 (NP_004612).
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
TRPC6 Gene(Protein Coding) Transient Receptor Potential Cation Channel Subfamily C Member 6
Introduction
TRPC6 forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene can cause focal segmental glomerulosclerosis 2 (FSGS2).
Entrez Gene ID
7225
UniProt ID
Q9Y210
Alternative Names
Transient Receptor Potential Cation Channel Subfamily C Member 6; Focal Segmental Glomerulosclerosis 2; Transient Receptor Protein 6; TRP-6; TRP6; Transient Receptor Potential Cation Channel, Subfamily C, Member 6; Short Transient Receptor Potential Channel 6; FSGS2; TrpC6
Function
Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369).
Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346).
Seems not to be activated by intracellular calcium store depletion.
Biological Process
Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process cation transport Source:ProtInc1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process positive regulation of calcium ion transport Source:MGI1 Publication
Biological Process positive regulation of cytosolic calcium ion concentration Source:Ensembl
Biological Process positive regulation of ion transmembrane transporter activity Source:MGI1 Publication
Biological Process regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Biological Process single fertilization Source:GO_Central1 Publication
Cellular Location
Cell membrane
Involvement in disease
Focal segmental glomerulosclerosis 2 (FSGS2):
A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Topology
Cytoplasmic: 1-438
Helical: 439-459
Extracellular: 460-487
Helical: 488-508
Cytoplasmic: 509-521
Helical: 522-542
Extracellular: 543-592
Helical: 593-613
Cytoplasmic: 614-636
Helical: 637-657
Extracellular: 658-706
Helical: 707-727
Cytoplasmic: 728-931
PTM
Phosphorylated by FYN, leading to an increase of TRPC6 channel activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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