Mouse Anti-TRPC6 Recombinant Antibody (3F2.H10.F2) (CBMAB-T4457-YJ)

Name: Mouse Anti-TRPC6 Recombinant Antibody (3F2.H10.F2)
SKU: CBMAB-T4457-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3F2.H10.F2

Application

WB, ELISA, IHC-P

Immunogen

Synthetic peptide corresponding to a region near the C terminal of Human TRPC6 (NP_004612).

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

C-terminus

More Infomation

Target

Full Name

TRPC6 Gene(Protein Coding) Transient Receptor Potential Cation Channel Subfamily C Member 6

Introduction

TRPC6 forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene can cause focal segmental glomerulosclerosis 2 (FSGS2).

Entrez Gene ID

7225

UniProt ID

Q9Y210

Alternative Names

Transient Receptor Potential Cation Channel Subfamily C Member 6; Focal Segmental Glomerulosclerosis 2; Transient Receptor Protein 6; TRP-6; TRP6; Transient Receptor Potential Cation Channel, Subfamily C, Member 6; Short Transient Receptor Potential Channel 6; FSGS2; TrpC6

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369).
Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346).
Seems not to be activated by intracellular calcium store depletion.

Biological Process

Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process cation transport Source:ProtInc1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process positive regulation of calcium ion transport Source:MGI1 Publication
Biological Process positive regulation of cytosolic calcium ion concentration Source:Ensembl
Biological Process positive regulation of ion transmembrane transporter activity Source:MGI1 Publication
Biological Process regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Biological Process single fertilization Source:GO_Central1 Publication

Cellular Location

Cell membrane

Involvement in disease

Focal segmental glomerulosclerosis 2 (FSGS2):
A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.

Topology

Cytoplasmic: 1-438
Helical: 439-459
Extracellular: 460-487
Helical: 488-508
Cytoplasmic: 509-521
Helical: 522-542
Extracellular: 543-592
Helical: 593-613
Cytoplasmic: 614-636
Helical: 637-657
Extracellular: 658-706
Helical: 707-727
Cytoplasmic: 728-931

PTM

Phosphorylated by FYN, leading to an increase of TRPC6 channel activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TRPC6 Recombinant Antibody (CBYJT-4908) (CAT#: CBMAB-T4456-YJ)

Mouse Anti-TRPC6 Recombinant Antibody (CBYJT-4910) (CAT#: CBMAB-T4459-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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