TRPV2

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.

Full Name

TRPV2 Gene(Protein Coding)

Transient Receptor Potential Cation Channel Subfamily V Member 2

Function

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.

Biological Process

Biological Process calcium ion import across plasma membrane Source:GO_Central1 Publication
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process positive regulation of axon extension Source:Ensembl
Biological Process positive regulation of calcium ion import Source:Ensembl
Biological Process positive regulation of cold-induced thermogenesis Source:YuBioLabBy Similarity
Biological Process response to heat Source:InterPro
Biological Process response to temperature stimulus Source:MGI1 Publication
Biological Process sensory perception Source:ProtInc1 Publication

Cellular Location

Cell membrane
Cytoplasm
Melanosome
Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV

Topology

Cytoplasmic: 1-390
Helical: 391-411
Extracellular: 412-434
Helical: 435-455
Cytoplasmic: 456-471
Helical: 472-492
Extracellular: 493
Helical: 494-514
Cytoplasmic: 515-537
Helical: 538-558
Pore-forming: 572-609
Helical: 622-642
Cytoplasmic: 643-764

PTM

N-glycosylated.
Phosphorylated by PKA.