Mouse Anti-TRPV2 Recombinant Antibody (B-9) (CBMAB-V0033-YC)

Name: Mouse Anti-TRPV2 Recombinant Antibody (B-9)
SKU: CBMAB-V0033-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

B-9

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TRPV2 Gene(Protein Coding)

Transient Receptor Potential Cation Channel Subfamily V Member 2

Introduction

TRPV2 is an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia.

Entrez Gene ID

51393

UniProt ID

Q9Y5S1

Alternative Names

Transient Receptor Potential Cation Channel Subfamily V Member 2; Vanilloid Receptor-Like Protein 1; Osm-9-Like TRP Channel 2; OTRPC2; VRL-1; VRL; Transient Receptor Potential Cation Channel, Subfamily V, Member 2; TrpV2; VRL1

Function

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.

Biological Process

Biological Process calcium ion import across plasma membrane Source:GO_Central1 Publication
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process positive regulation of axon extension Source:Ensembl
Biological Process positive regulation of calcium ion import Source:Ensembl
Biological Process positive regulation of cold-induced thermogenesis Source:YuBioLabBy Similarity
Biological Process response to heat Source:InterPro
Biological Process response to temperature stimulus Source:MGI1 Publication
Biological Process sensory perception Source:ProtInc1 Publication

Cellular Location

Cell membrane
Cytoplasm
Melanosome
Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV

Topology

Cytoplasmic: 1-390
Helical: 391-411
Extracellular: 412-434
Helical: 435-455
Cytoplasmic: 456-471
Helical: 472-492
Extracellular: 493
Helical: 494-514
Cytoplasmic: 515-537
Helical: 538-558
Pore-forming: 572-609
Helical: 622-642
Cytoplasmic: 643-764

PTM

N-glycosylated.
Phosphorylated by PKA.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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