TTK

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

TTK Gene(Protein Coding) TTK Protein Kinase

Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720).
Probably associated with cell proliferation (PubMed:18243099).
Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720).
Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099).

Biological Process chromosome segregation Source:GO_Central1 Publication
Biological Process chromosome separation Source:InterPro
Biological Process female meiosis chromosome segregation Source:Ensembl
Biological Process meiotic spindle assembly checkpoint signaling Source:GO_Central1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:GO_Central1 Publication
Biological Process mitotic spindle organization Source:ProtInc1 Publication
Biological Process peptidyl-serine phosphorylation Source:GO_Central1 Publication
Biological Process peptidyl-threonine phosphorylation Source:Ensembl
Biological Process positive regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process positive regulation of pathway-restricted SMAD protein phosphorylation Source:BHF-UCL1 Publication
Biological Process protein autophosphorylation Source:Ensembl
Biological Process protein localization to kinetochore Source:GO_Central1 Publication
Biological Process protein localization to meiotic spindle midzone Source:Ensembl
Biological Process spindle organization Source:ProtInc1 Publication

cytoplasm
kinetochore
membrane
nucleus
spindle