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Mouse Anti-TTK Recombinant Antibody (4G9) (CBMAB-A9611-LY)

The product is antibody recognizes TTK. The antibody 4G9 immunoassay techniques such as: WB, ELISA.
See all TTK antibodies
Published Data
Fig.1 Mps1 controls ciliary diassembly during serum stimulation.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4G9
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TTK (AAH00633, 1 a.a. ~ 176 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TTK Gene(Protein Coding) TTK Protein Kinase
Entrez Gene ID
7272
UniProt ID
P33981
Alternative Names
ESK; FLJ38280; MPS1; MPS1L1; PYT
Function
Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720).
Probably associated with cell proliferation (PubMed:18243099).
Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720).
Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099).
Biological Process
Biological Process chromosome segregation Source:GO_Central1 Publication
Biological Process chromosome separation Source:InterPro
Biological Process female meiosis chromosome segregation Source:Ensembl
Biological Process meiotic spindle assembly checkpoint signaling Source:GO_Central1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:GO_Central1 Publication
Biological Process mitotic spindle organization Source:ProtInc1 Publication
Biological Process peptidyl-serine phosphorylation Source:GO_Central1 Publication
Biological Process peptidyl-threonine phosphorylation Source:Ensembl
Biological Process positive regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process positive regulation of pathway-restricted SMAD protein phosphorylation Source:BHF-UCL1 Publication
Biological Process protein autophosphorylation Source:Ensembl
Biological Process protein localization to kinetochore Source:GO_Central1 Publication
Biological Process protein localization to meiotic spindle midzone Source:Ensembl
Biological Process spindle organization Source:ProtInc1 Publication
Cellular Location
cytoplasm
kinetochore
membrane
nucleus
spindle
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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