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Mouse Anti-TTK (AA 3-856) Recombinant Antibody (CBFYM-3173) (CBMAB-M3370-FY)

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Basic Information

Host Animal
Mouse
Clone
CBFYM-3173
Application
ICC, WB
Immunogen
His-tagged fusion protein corresponding to aa3-856 of human Mps1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1 M Tris-Glycine, pH 7.4, 0.15 M NaCl
Preservative
0.05% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 3-856
More Infomation

Target

Full Name
TTK Gene(Protein Coding) TTK Protein Kinase
Introduction
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
7272
UniProt ID
P33981
Alternative Names
TTK Protein Kinase; Phosphotyrosine Picked Threonine-Protein Kinase; Monopolar Spindle 1 Kinase; Cancer/Testis Antigen 96; MPS1L1; MPS1; PYT; Phosphotyrosine Picked Threonine Kinase
Function
Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720).
Probably associated with cell proliferation (PubMed:18243099).
Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720).
Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099).
Biological Process
Biological Process chromosome segregation Source:GO_Central1 Publication
Biological Process chromosome separation Source:InterPro
Biological Process female meiosis chromosome segregation Source:Ensembl
Biological Process meiotic spindle assembly checkpoint signaling Source:GO_Central1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:GO_Central1 Publication
Biological Process mitotic spindle organization Source:ProtInc1 Publication
Biological Process peptidyl-serine phosphorylation Source:GO_Central1 Publication
Biological Process peptidyl-threonine phosphorylation Source:Ensembl
Biological Process positive regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process positive regulation of pathway-restricted SMAD protein phosphorylation Source:BHF-UCL1 Publication
Biological Process protein autophosphorylation Source:Ensembl
Biological Process protein localization to kinetochore Source:GO_Central1 Publication
Biological Process protein localization to meiotic spindle midzone Source:Ensembl
Biological Process spindle organization Source:ProtInc1 Publication
Cellular Location
cytoplasm
kinetochore
membrane
nucleus
spindle
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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