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Mouse Anti-TTK Recombinant Antibody (CBYJT-5154) (CBMAB-T4732-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TTK (TTK Protein Kinase). The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC-P.
See all TTK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5154
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IHC-P

Basic Information

Immunogen
GST fusion protein
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TTK Gene(Protein Coding) TTK Protein Kinase
Introduction
TTK is a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. TTK has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles.
Entrez Gene ID
7272
UniProt ID
P33981
Alternative Names
TTK Protein Kinase; Phosphotyrosine Picked Threonine-Protein Kinase; Monopolar Spindle 1 Kinase; Cancer/Testis Antigen 96; MPS1L1; MPS1; PYT; Phosphotyrosine Picked Threonine Kinase
Function
Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720).
Probably associated with cell proliferation (PubMed:18243099).
Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720).
Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099).
Biological Process
Biological Process chromosome segregation Source:GO_Central1 Publication
Biological Process chromosome separation Source:InterPro
Biological Process female meiosis chromosome segregation Source:Ensembl
Biological Process meiotic spindle assembly checkpoint signaling Source:GO_Central1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:GO_Central1 Publication
Biological Process mitotic spindle organization Source:ProtInc1 Publication
Biological Process peptidyl-serine phosphorylation Source:GO_Central1 Publication
Biological Process peptidyl-threonine phosphorylation Source:Ensembl
Biological Process positive regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process positive regulation of pathway-restricted SMAD protein phosphorylation Source:BHF-UCL1 Publication
Biological Process protein autophosphorylation Source:Ensembl
Biological Process protein localization to kinetochore Source:GO_Central1 Publication
Biological Process protein localization to meiotic spindle midzone Source:Ensembl
Biological Process spindle organization Source:ProtInc1 Publication
Cellular Location
cytoplasm
kinetochore
membrane
nucleus
spindle
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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