UCHL5

Protease that specifically cleaves Lys-48-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Full Name

UCHL5

Function

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Biological Process

Biological Process chromatin remodeling Source:ComplexPortal1 Publication
Biological Process DNA recombination Source:UniProtKB-KW
Biological Process DNA repair Source:UniProtKB-KW
Biological Process forebrain morphogenesis Source:Ensembl
Biological Process lateral ventricle development Source:Ensembl
Biological Process midbrain development Source:Ensembl
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process positive regulation of DNA repair Source:ComplexPortal
Biological Process positive regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process positive regulation of smoothened signaling pathway Source:FlyBase1 Publication
Biological Process positive regulation of telomere maintenance in response to DNA damage Source:ComplexPortal
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of cell cycle Source:ComplexPortal1 Publication
Biological Process regulation of chromosome organization Source:ComplexPortal1 Publication
Biological Process regulation of DNA repair Source:ComplexPortal
Biological Process regulation of DNA replication Source:ComplexPortal1 Publication
Biological Process regulation of DNA strand elongation Source:ComplexPortal1 Publication
Biological Process regulation of embryonic development Source:ComplexPortal
Biological Process regulation of proteasomal protein catabolic process Source:UniProtKB1 Publication
Biological Process telomere maintenance Source:ComplexPortal
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

Cytoplasm
Nucleus
Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus.