Sign in or Register   Sign in or Register
  |  

UCP2

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
Full Name
Uncoupling Protein 2
Function
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Biological Process
Biological Process adaptive thermogenesis Source:GO_Central1 Publication
Biological Process aging Source:Ensembl
Biological Process cellular response to amino acid starvation Source:Ensembl
Biological Process cellular response to glucose stimulus Source:Ensembl
Biological Process cellular response to insulin stimulus Source:Ensembl
Biological Process female pregnancy Source:Ensembl
Biological Process liver regeneration Source:Ensembl
Biological Process mitochondrial transmembrane transport Source:GO_Central1 Publication
Biological Process mitochondrial transport Source:Ensembl
Biological Process negative regulation of apoptotic process Source:Ensembl
Biological Process negative regulation of insulin secretion involved in cellular response to glucose stimulus Source:Ensembl
Biological Process positive regulation of cell death Source:Ensembl
Biological Process positive regulation of cold-induced thermogenesis Source:YuBioLabBy Similarity
Biological Process proton transmembrane transport Source:ProtInc1 Publication
Biological Process regulation of mitochondrial membrane potential Source:Ensembl
Biological Process response to cold Source:GO_Central1 Publication
Biological Process response to fatty acid Source:Ensembl
Biological Process response to hypoxia Source:CACAO1 Publication
Biological Process response to superoxide Source:Ensembl
Cellular Location
Mitochondrion inner membrane
Topology
Mitochondrial intermembrane: 1-10
Helical: 11-32
Mitochondrial matrix: 33-77
Helical: 78-100
Mitochondrial intermembrane: 101-119
Helical: 120-136
Mitochondrial matrix: 137-180
Helical: 181-197
Mitochondrial intermembrane: 198-214
Helical: 215-234
Mitochondrial matrix: 235-268
Helical: 269-291
Mitochondrial intermembrane: 292-309

Anti-UCP2 antibodies

Loading...
Target: UCP2
Host: Mouse
Specificity: Human
Clone: 3F1B9
Application*: FC
Target: UCP2
Host: Mouse
Specificity: Human
Clone: 6C8B3
Application*: FC
Target: UCP2
Host: Rabbit
Specificity: Human, Monkey, Mouse, Rat
Clone: D1O5V
Application*: WB
Target: UCP2
Host: Mouse
Specificity: Human
Clone: CBXS-0937
Application*: WB, IC, P, C, E
Target: UCP2
Host: Mouse
Specificity: Rat
Clone: CBXS-0938
Application*: WB, IC, P, C, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare