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Mouse Anti-UCP2 Recombinant Antibody (CBT3676) (V2LY-0625-LY446)

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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3676
Antibody Isotype
IgG2a
Application
ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human UCP2 (AA: 1-309) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Uncoupling Protein 2
Entrez Gene ID
Function
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Biological Process
Biological Process adaptive thermogenesis Source:GO_Central1 Publication
Biological Process aging Source:Ensembl
Biological Process cellular response to amino acid starvation Source:Ensembl
Biological Process cellular response to glucose stimulus Source:Ensembl
Biological Process cellular response to insulin stimulus Source:Ensembl
Biological Process female pregnancy Source:Ensembl
Biological Process liver regeneration Source:Ensembl
Biological Process mitochondrial transmembrane transport Source:GO_Central1 Publication
Biological Process mitochondrial transport Source:Ensembl
Biological Process negative regulation of apoptotic process Source:Ensembl
Biological Process negative regulation of insulin secretion involved in cellular response to glucose stimulus Source:Ensembl
Biological Process positive regulation of cell death Source:Ensembl
Biological Process positive regulation of cold-induced thermogenesis Source:YuBioLabBy Similarity
Biological Process proton transmembrane transport Source:ProtInc1 Publication
Biological Process regulation of mitochondrial membrane potential Source:Ensembl
Biological Process response to cold Source:GO_Central1 Publication
Biological Process response to fatty acid Source:Ensembl
Biological Process response to hypoxia Source:CACAO1 Publication
Biological Process response to superoxide Source:Ensembl
Cellular Location
Mitochondrion inner membrane
Topology
Mitochondrial intermembrane: 1-10
Helical: 11-32
Mitochondrial matrix: 33-77
Helical: 78-100
Mitochondrial intermembrane: 101-119
Helical: 120-136
Mitochondrial matrix: 137-180
Helical: 181-197
Mitochondrial intermembrane: 198-214
Helical: 215-234
Mitochondrial matrix: 235-268
Helical: 269-291
Mitochondrial intermembrane: 292-309
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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