ULBP2

This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]

UL16 Binding Protein 2

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Biological Process natural killer cell activation Source:UniProtKB1 Publication
Biological Process natural killer cell mediated cytotoxicity Source:UniProtKB1 Publication

Cell membrane
Endoplasmic reticulum
Secreted
In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi.