Mouse Anti-ULBP2 Recombinant Antibody (14L966) (CBMAB-C4589-CN)

Name: Mouse Anti-ULBP2 Recombinant Antibody (14L966)
SKU: CBMAB-C4589-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

14L966

Application

FC, Neut

Immunogen

Recombinant protein corresponding to human ULBP-2

Specificity

Human

Antibody Isotype

IgG2

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS. Reconstitute with 0.2 mL of sterile PBS

Concentration

0.5 mg/mL (after reconstitution)

More Infomation

Target

Full Name

UL16 Binding Protein 2

Introduction

This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]

Entrez Gene ID

80328

UniProt ID

Q9BZM5

Alternative Names

UL16 Binding Protein 2; Retinoic Acid Early Transcript 1H; NKG2D Ligand 2; ALCAN-Alpha; NKG2DL2; RAET1H; N2DL2; UL16-Binding Protein 2; N2DL-2;

Function

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Biological Process

Biological Process natural killer cell activation Source:UniProtKB1 Publication
Biological Process natural killer cell mediated cytotoxicity Source:UniProtKB1 Publication

Cellular Location

Cell membrane
Endoplasmic reticulum
Secreted
In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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