USP47

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.

Full Name

ubiquitin specific peptidase 47

Function

Biological Process

Biological Process base-excision repair Source:UniProtKB1 Publication
Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process cellular response to UV Source:UniProtKBBy Similarity
Biological Process intrinsic apoptotic signaling pathway in response to DNA damage Source:Ensembl
Biological Process monoubiquitinated protein deubiquitination Source:UniProtKB1 Publication
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of G2/M transition of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source:Ensembl
Biological Process positive regulation of canonical Wnt signaling pathway Source:FlyBase1 Publication
Biological Process positive regulation of cell growth Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:GO_Central1 Publication
Biological Process regulation of protein stability Source:GO_Central1 Publication
Biological Process response to xenobiotic stimulus Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

Cytoplasm