UTRN
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq]
Full Name
utrophin
Function
May play a role in anchoring the cytoskeleton to the plasma membrane.
Biological Process
Biological Process actin cytoskeleton organization Source:GO_Central1 Publication
Biological Process muscle contraction Source:ProtInc1 Publication
Biological Process muscle organ development Source:ProtInc1 Publication
Biological Process positive regulation of cell-matrix adhesion Source:UniProtKB1 Publication
Biological Process regulation of sodium ion transmembrane transporter activity Source:BHF-UCLBy Similarity
Biological Process muscle contraction Source:ProtInc1 Publication
Biological Process muscle organ development Source:ProtInc1 Publication
Biological Process positive regulation of cell-matrix adhesion Source:UniProtKB1 Publication
Biological Process regulation of sodium ion transmembrane transporter activity Source:BHF-UCLBy Similarity
Cellular Location
Postsynaptic cell membrane
Cytoplasm, cytoskeleton
Neuromuscular junction.
Cytoplasm, cytoskeleton
Neuromuscular junction.
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Anti-UTRN antibodies
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CompareTarget: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXU-007
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5G6
Application*: E, IF, WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7C11
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10A7
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A10
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10D4
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8C11
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6H4
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4E3
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5C9
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5E10
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 8A3
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2A5
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4B12
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B3
Application*: WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B6
Application*: WB, IF
Target: UTRN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 7F3
Application*: IF, IH, WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Mouse, Frog
Clone: 2G5
Application*: IF, IH, WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Mouse, Frog
Clone: 8A4
Application*: IF, IH, WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Mouse, Frog
Clone: 9G3
Application*: WB, IF
Target: UTRN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Fish, Mouse, Frog
Clone: 3C1
Application*: IF, WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Common fruit fly, Fish, Mouse
Clone: 4C8
Application*: IF, WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 40
Application*: IF, WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G12
Application*: IF, WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Fish, Mouse
Clone: 9F2
Application*: IF, WB
Target: UTRN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9E10
Application*: WB, IF
Target: UTRN
Sensitivity: 0.108 ng/mL
Detection Range: 0.2-60 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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