VAX2

This gene encodes a homeo-domain containing protein from a class of homeobo x transcription factors which are conserved in vertebrates. Genes of this family are involved in the regulation of bo dy development and morphogenesis. The most conserved genes, called HOX genes are found in special gene clusters. This gene belongs to the VAX subfamily and lies in the vicinity of the EMX homeobo x gene family. Another member of VAX family is located on chromosome 2. The encoded protein may play an important role in the development of anterior ventral forebrain and visual system. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

Ventral Anterior HomeoBovinex 1

Function

Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity).
May be a regulator of axial polarization in the retina.

Biological Process

Biological Process axonogenesis Source:Ensembl
Biological Process central nervous system development Source:GO_Central1 Publication
Biological Process dorsal/ventral axis specification Source:Ensembl
Biological Process ectoderm development Source:ProtInc1 Publication
Biological Process embryonic eye morphogenesis Source:Ensembl
Biological Process forebrain development Source:UniProtKB
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process retina development in camera-type eye Source:Ensembl
Biological Process visual perception Source:ProtInc1 Publication
Biological Process Wnt signaling pathway Source:UniProtKB-KW

Cellular Location

Nucleus