VCPIP1

VCPIP1 (Valosin Containing Protein Interacting Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity.

Full Name

valosin containing protein (p97)/p47 complex interacting protein 1

Function

Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882).
Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity).
Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity).
Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity).
Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882).
Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681).
(Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients.

Biological Process

Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process endoplasmic reticulum membrane fusion Source:GO_Central1 Publication
Biological Process Golgi reassembly Source:GO_Central1 Publication
Biological Process mitotic cell cycle Source:Ensembl
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process protein K11-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein K48-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:UniProtKB
Biological Process protein-DNA covalent cross-linking repair Source:UniProtKB1 Publication
Biological Process regulation of protein localization to chromatin Source:UniProtKB1 Publication

Cellular Location

Nucleus
Cytoplasm
Endoplasmic reticulum
Golgi apparatus, Golgi stack
Associated with Golgi stacks and endoplasmic reticulum (By similarity).
Displays cytoplasmic to nuclear translocation in response to DNA-protein cross-links (DPCs)-inducing agents (PubMed:32649882).

PTM

Phosphorylated at Ser-1207 by ATM or ATR following induction of covalent DNA-protein cross-links (DPCs).