Mouse Anti-VCPIP1 Recombinant Antibody (CBYY-1390) (CBMAB-1436-YY)

Name: Mouse Anti-VCPIP1 Recombinant Antibody (CBYY-1390)
SKU: CBMAB-1436-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYY-1390

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

valosin containing protein (p97)/p47 complex interacting protein 1

Introduction

VCPIP1 (Valosin Containing Protein Interacting Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity.

Entrez Gene ID

80124

UniProt ID

Q96JH7

Alternative Names

Valosin Containing Protein Interacting Protein 1; Valosin-Containing Protein P97/P47 Complex-Interacting Protein P135; Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1; VCP/P47 Complex-Interacting 135-KDa Protein; VCIP135; Valosin Containing Protein (P97)/P47 Complex Interacting Protein 1;

Function

Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882).
Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity).
Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity).
Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity).
Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882).
Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681).
(Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients.

Biological Process

Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process endoplasmic reticulum membrane fusion Source:GO_Central1 Publication
Biological Process Golgi reassembly Source:GO_Central1 Publication
Biological Process mitotic cell cycle Source:Ensembl
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process protein K11-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein K48-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:UniProtKB
Biological Process protein-DNA covalent cross-linking repair Source:UniProtKB1 Publication
Biological Process regulation of protein localization to chromatin Source:UniProtKB1 Publication

Cellular Location

Nucleus
Cytoplasm
Endoplasmic reticulum
Golgi apparatus, Golgi stack
Associated with Golgi stacks and endoplasmic reticulum (By similarity).
Displays cytoplasmic to nuclear translocation in response to DNA-protein cross-links (DPCs)-inducing agents (PubMed:32649882).

PTM

Phosphorylated at Ser-1207 by ATM or ATR following induction of covalent DNA-protein cross-links (DPCs).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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