VPS25

VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS25, VPS36, and SNF8 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM

Full Name

vacuolar protein sorting 25 homolog (S. cerevisiae)

Function

Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.

Biological Process

Biological Process macroautophagy Source:ParkinsonsUK-UCL1 Publication
Biological Process membrane fission Source:ComplexPortal1 Publication
Biological Process multivesicular body assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of epidermal growth factor-activated receptor activity Source:UniProtKB1 Publication
Biological Process protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source:GO_Central1 Publication

Cellular Location

Cytoplasm
Endosome membrane
Nucleus, nucleoplasm
Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6.