VPS8

VPS8 (VPS8, CORVET Complex Subunit) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

VPS8, CORVET Complex Subunit

Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290).
Functions predominantly in APPL1-containing endosomes (PubMed:25266290).

Biological Process endosomal vesicle fusion Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process regulation of SNARE complex assembly Source:ComplexPortal1 Publication

Early endosome