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Mouse Anti-VPS8 Recombinant Antibody (2C8) (CBMAB-A4678-LY)

The product is antibody recognizes KIAA0804. The antibody 2C8 immunoassay techniques such as: WB, ELISA.
See all VPS8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C8
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
KIAA0804 (NP_001009921, 1329 a.a. ~ 1428 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
VPS8, CORVET Complex Subunit
Entrez Gene ID
23355
UniProt ID
Q8N3P4
Alternative Names
FLJ32099; KIAA0804
Function
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290).
Functions predominantly in APPL1-containing endosomes (PubMed:25266290).
Biological Process
Biological Process endosomal vesicle fusion Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process regulation of SNARE complex assembly Source:ComplexPortal1 Publication
Cellular Location
Early endosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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