VTN2

NF-κB (nuclear factor kappaB) is a transcription factor that activates numerous target genes important in mediating innate and adaptive immunity in mammals. Activation by external stimuli such as TNF leads to the activation of kinases (IKK1 and IKK2) that phosphorylate inhibitory proteins I-κB and their subsequent degradation. IKK1 and IKK2 form the catalytic subunits of a complex which includes IKKγ, the regulatory component (also known as NEMO). Mutations in NEMO are the cause of the human disorders incontinentia pigmenti and ectodermal dysplasia (ED-AID).

Splice Variant of Zebrafish IKKg Protein