WDR12

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.

Full Name

WDR12

Function

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Biological Process

Biological Process maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source:UniProtKB1 Publication
Biological Process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source:UniProtKB2 Publications
Biological Process Notch signaling pathway Source:Ensembl
Biological Process regulation of cell cycle Source:UniProtKB1 Publication
Biological Process ribosomal large subunit biogenesis Source:UniProtKB2 Publications

Cellular Location

Nucleus, nucleolus
Nucleus, nucleoplasm