WDR66

WDR66 is a protein-coding gene encodes the protein which belongs to the WD repeat-containing family of proteins and function in the formation of protein-protein complexes in a variety of biological pathways. Gene Ontology (GO) annotations related to this gene include calcium ion binding.

Full Name

WD repeat domain 66

Function

Involved in spermatozoa motility (PubMed:30122540, PubMed:30122541).
May also regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity).

Biological Process

Biological Process cilium movement Source:UniProtKB
Biological Process flagellated sperm motility Source:UniProtKB1 Publication

Cellular Location

Cytoplasm, cytoskeleton, cilium axoneme
Cell projection, cilium, flagellum

Involvement in disease

Spermatogenic failure 33 (SPGF33):
An autosomal recessive infertility disorder caused by spermatogenesis defects that result in multiple abnormalities of sperm flagellum, including short, bent, curled, thick, or absent flagella.

Anti-WDR66 antibodies

Mouse Anti-WDR66 Recombinant Antibody (2A6F7) (CBMAB-W0065-WJ)

Datasheet

SDS

Target: WDR66

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2A6F7

Application*: WB, F, E, MC

Mouse Anti-WDR66 Recombinant Antibody (CBWJW-203) (CBMAB-W0022-WJ)

Datasheet

SDS

Target: WDR66

Host: Mouse

Specificity: Human

Clone: CBWJW-203

Application*: E, F, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)