WDR74

WDR74 (WD Repeat Domain 74) is a Protein Coding gene.

Full Name

WD Repeat Domain 74

Function

Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit (PubMed:26456651).
Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (PubMed:29107693).
Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity).

Biological Process

Biological Process blastocyst formation Source:UniProtKB
Biological Process ribosomal large subunit biogenesis Source:UniProtKB1 Publication
Biological Process RNA metabolic process Source:UniProtKB
Biological Process rRNA processing Source:UniProtKB1 Publication

Cellular Location

Nucleus, nucleolus
Nucleus
Nucleolar location depends on active PolI transcription of pre-rRNA.

Anti-WDR74 antibodies

Mouse Anti-WDR74 Recombinant Antibody (3D10) (CBMAB-W0092-WJ)

Datasheet

SDS

Target: WDR74

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3D10

Application*: WB

Mouse Anti-WDR74 Recombinant Antibody (4B2) (CBMAB-W0108-WJ)

Datasheet

SDS

Target: WDR74

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4B2

Application*: P, WB

Mouse Anti-WDR74 Recombinant Antibody (4F2) (CBMAB-W0116-WJ)

Datasheet

SDS

Target: WDR74

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4F2

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)