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WDR74

WDR74 (WD Repeat Domain 74) is a Protein Coding gene.

Full Name

WD Repeat Domain 74

Function

Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit (PubMed:26456651).
Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (PubMed:29107693).
Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity).

Biological Process

Biological Process blastocyst formation Source:UniProtKB
Biological Process ribosomal large subunit biogenesis Source:UniProtKB1 Publication
Biological Process RNA metabolic process Source:UniProtKB
Biological Process rRNA processing Source:UniProtKB1 Publication

Cellular Location

Nucleus, nucleolus
Nucleus
Nucleolar location depends on active PolI transcription of pre-rRNA.

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Anti-WDR74 antibodies

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Mouse Anti-WDR74 Recombinant Antibody (4F2) (CBMAB-W0116-WJ)

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Target: WDR74

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4F2

Application*: WB

Mouse Anti-WDR74 Recombinant Antibody (4B2) (CBMAB-W0108-WJ)

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Target: WDR74

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4B2

Application*: P, WB

Mouse Anti-WDR74 Recombinant Antibody (3D10) (CBMAB-W0092-WJ)

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Target: WDR74

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3D10

Application*: WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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