WDR82

TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]

Full Name

WD Repeat Domain 82

Function

Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes (PubMed:17998332, PubMed:18838538, PubMed:20516061).
Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (PubMed:17998332, PubMed:18838538).
Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061).
Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33913806, PubMed:33767452).
The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452).

Biological Process

Biological Process DNA-templated transcription termination Source:UniProtKB-KW
Biological Process histone H3-K4 methylation Source:ComplexPortal1 Publication
Biological Process histone H3-K4 trimethylation Source:GO_Central1 Publication
Biological Process lncRNA catabolic process Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription, elongation Source:UniProtKB1 Publication
Biological Process negative regulation of lncRNA transcription Source:UniProtKB1 Publication
Biological Process nuclear RNA surveillance Source:UniProtKB1 Publication

Cellular Location

Nucleus
Chromosome
Associates with chromatin (PubMed:20516061).
Recruited at sites of high RNA polymerase II occupancy (By similarity).