Rabbit Anti-WDR82 Recombinant Antibody (CBWJW-018) (CBMAB-W0175-WJ)

Name: Rabbit Anti-WDR82 Recombinant Antibody (CBWJW-018)
SKU: CBMAB-W0175-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBWJW-018

Application

WB, IP

Specificity

Human, Mouse, Monkey, Hamster, Horse

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

WD Repeat Domain 82

Introduction

WDR82 is a protein-coding gene encodesa component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes. Among its related pathways are Chromatin Regulation / Acetylation and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include chromatin binding and histone methyltransferase activity (H3-K4 specific).

Entrez Gene ID

Human	80335
Mouse	77305
Hamster	101843489
Horse	100060351
Monkey	697708

UniProt ID

Human	Q6UXN9
Mouse	Q8BFQ4
Hamster	A0A1U7QUE3
Horse	F7C804
Monkey	F7HSB5

Alternative Names

SWD2; MST107; WDR82A; MSTP107; PRO2730; TMEM113; PRO34047

Function

Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes (PubMed:17998332, PubMed:18838538, PubMed:20516061).
Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (PubMed:17998332, PubMed:18838538).
Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061).
Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33913806, PubMed:33767452).
The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452).

Biological Process

Biological Process DNA-templated transcription termination Source:UniProtKB-KW
Biological Process histone H3-K4 methylation Source:ComplexPortal1 Publication
Biological Process histone H3-K4 trimethylation Source:GO_Central1 Publication
Biological Process lncRNA catabolic process Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription, elongation Source:UniProtKB1 Publication
Biological Process negative regulation of lncRNA transcription Source:UniProtKB1 Publication
Biological Process nuclear RNA surveillance Source:UniProtKB1 Publication

Cellular Location

Nucleus
Chromosome
Associates with chromatin (PubMed:20516061).
Recruited at sites of high RNA polymerase II occupancy (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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