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Rabbit Anti-WDR82 Recombinant Antibody (CBWJW-018) (CBMAB-W0175-WJ)

This product is a rabbit antibody that recognizes WDR82. The antibody CBWJW-018 can be used for immunoassay techniques such as: WB, IP.
See all WDR82 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Monkey, Hamster, Horse
Clone
CBWJW-018
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Monkey, Hamster, Horse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WD Repeat Domain 82
Introduction
WDR82 is a protein-coding gene encodesa component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes. Among its related pathways are Chromatin Regulation / Acetylation and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include chromatin binding and histone methyltransferase activity (H3-K4 specific).
Entrez Gene ID
Human80335
Mouse77305
Hamster101843489
Horse100060351
Monkey697708
UniProt ID
HumanQ6UXN9
MouseQ8BFQ4
HamsterA0A1U7QUE3
HorseF7C804
MonkeyF7HSB5
Alternative Names
SWD2; MST107; WDR82A; MSTP107; PRO2730; TMEM113; PRO34047
Function
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes (PubMed:17998332, PubMed:18838538, PubMed:20516061).
Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (PubMed:17998332, PubMed:18838538).
Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061).
Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33913806, PubMed:33767452).
The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452).
Biological Process
Biological Process DNA-templated transcription termination Source:UniProtKB-KW
Biological Process histone H3-K4 methylation Source:ComplexPortal1 Publication
Biological Process histone H3-K4 trimethylation Source:GO_Central1 Publication
Biological Process lncRNA catabolic process Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription, elongation Source:UniProtKB1 Publication
Biological Process negative regulation of lncRNA transcription Source:UniProtKB1 Publication
Biological Process nuclear RNA surveillance Source:UniProtKB1 Publication
Cellular Location
Nucleus
Chromosome
Associates with chromatin (PubMed:20516061).
Recruited at sites of high RNA polymerase II occupancy (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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