WISP1

WISP1 is a protein-coding gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. Gene Ontology (GO) annotations related to this gene include heparin binding and insulin-like growth factor binding. An important paralog of this gene is CTGF.

Full Name

WNT1 inducible signaling pathway protein 1

Function

Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.

Biological Process

Biological Process bone development Source:Ensembl
Biological Process cell adhesion Source:GO_Central1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process glucose homeostasis Source:Ensembl
Biological Process negative regulation of cell death Source:GO_Central1 Publication
Biological Process negative regulation of chondrocyte differentiation Source:Ensembl
Biological Process negative regulation of fat cell differentiation Source:Ensembl
Biological Process osteoblast differentiation Source:Ensembl
Biological Process osteoclast differentiation Source:Ensembl
Biological Process positive regulation of inflammatory response Source:UniProtKB1 Publication
Biological Process positive regulation of osteoblast differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of smooth muscle cell migration Source:UniProtKB
Biological Process positive regulation of smooth muscle cell proliferation Source:UniProtKB
Biological Process positive regulation of Wnt signaling pathway Source:Ensembl
Biological Process positive regulation of wound healing Source:Ensembl
Biological Process regulation of cytokine production Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process Wnt signaling pathway Source:UniProtKB-KW

Cellular Location

Secreted