Mouse Anti-WISP1 Recombinant Antibody (CBWJW-104) (CBMAB-W0253-WJ)

Name: Mouse Anti-WISP1 Recombinant Antibody (CBWJW-104)
SKU: CBMAB-W0253-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBWJW-104

Application

Immunogen

Recombinant protein corresponding to human WISP-1.

Specificity

Human

Antibody Isotype

IgG2

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

WNT1 inducible signaling pathway protein 1

Introduction

WISP1 is a protein-coding gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. Gene Ontology (GO) annotations related to this gene include heparin binding and insulin-like growth factor binding. An important paralog of this gene is CTGF.

Entrez Gene ID

8840

UniProt ID

O95388

Alternative Names

CCN4; WISP1c; WISP1i; WISP1tc; WISP1-OT1; WISP1-UT1

Function

Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.

Biological Process

Biological Process bone development Source:Ensembl
Biological Process cell adhesion Source:GO_Central1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process glucose homeostasis Source:Ensembl
Biological Process negative regulation of cell death Source:GO_Central1 Publication
Biological Process negative regulation of chondrocyte differentiation Source:Ensembl
Biological Process negative regulation of fat cell differentiation Source:Ensembl
Biological Process osteoblast differentiation Source:Ensembl
Biological Process osteoclast differentiation Source:Ensembl
Biological Process positive regulation of inflammatory response Source:UniProtKB1 Publication
Biological Process positive regulation of osteoblast differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of smooth muscle cell migration Source:UniProtKB
Biological Process positive regulation of smooth muscle cell proliferation Source:UniProtKB
Biological Process positive regulation of Wnt signaling pathway Source:Ensembl
Biological Process positive regulation of wound healing Source:Ensembl
Biological Process regulation of cytokine production Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process Wnt signaling pathway Source:UniProtKB-KW

Cellular Location

Secreted

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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