Sign in or Register   Sign in or Register
  |  

Rat Anti-WISP1 Recombinant Antibody (6G22) (CBMAB-W0143-WJ)

This product is a rat antibody that recognizes WISP1. The antibody 6G22 can be used for immunoassay techniques such as: WB.
See all WISP1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
6G22
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Mouse recombinant protein WISP-1.
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WNT1 inducible signaling pathway protein 1
Introduction
WISP1 is a protein-coding gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. Gene Ontology (GO) annotations related to this gene include heparin binding and insulin-like growth factor binding. An important paralog of this gene is CTGF.
Entrez Gene ID
22402
UniProt ID
O54775
Alternative Names
CCN4; Elm1; AW146261
Function
Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.
Biological Process
Biological Process bone development Source:Ensembl
Biological Process cell adhesion Source:GO_Central1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process glucose homeostasis Source:Ensembl
Biological Process negative regulation of cell death Source:GO_Central1 Publication
Biological Process negative regulation of chondrocyte differentiation Source:Ensembl
Biological Process negative regulation of fat cell differentiation Source:Ensembl
Biological Process osteoblast differentiation Source:Ensembl
Biological Process osteoclast differentiation Source:Ensembl
Biological Process positive regulation of inflammatory response Source:UniProtKB1 Publication
Biological Process positive regulation of osteoblast differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of smooth muscle cell migration Source:UniProtKB
Biological Process positive regulation of smooth muscle cell proliferation Source:UniProtKB
Biological Process positive regulation of Wnt signaling pathway Source:Ensembl
Biological Process positive regulation of wound healing Source:Ensembl
Biological Process regulation of cytokine production Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process Wnt signaling pathway Source:UniProtKB-KW
Cellular Location
Secreted
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-WISP1 Recombinant Antibody (6G22)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare