WISP2

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq]
Full Name
WNT1 inducible signaling pathway protein 2
Function
May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
Biological Process
Biological Process cell adhesion Source:GO_Central1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process negative regulation of cell death Source:GO_Central1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Cellular Location
Secreted
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Anti-WISP2 antibodies

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Mouse Anti-WISP2 Recombinant Antibody (CBWJW-133) (CBMAB-W0281-WJ)

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Target: WISP2
Host: Mouse
Specificity: Human
Clone: CBWJW-133
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-WISP2 Recombinant Antibody (CBWJW-049) (CBMAB-W0203-WJ)

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Target: WISP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJW-049
Application*: E, P, WB
Datasheet SDS

Mouse Anti-WISP2 Recombinant Antibody (CBWJW-048) (CBMAB-W0202-WJ)

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Target: WISP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJW-048
Application*: WB
Datasheet SDS

Mouse Anti-WISP2 Recombinant Antibody (9E3) (CBMAB-W0157-WJ)

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Target: WISP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9E3
Application*: E, WB
Datasheet SDS

Mouse Anti-WISP2 Recombinant Antibody (5D11E11) (CBMAB-W0130-WJ)

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Target: WISP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5D11E11
Application*: E, WB
Datasheet SDS

Mouse Anti-WISP2 Recombinant Antibody (3D10) (CBMAB-W0090-WJ)

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Target: WISP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D10
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-WISP2 Recombinant Antibody (1E11) (CBMAB-W0039-WJ)

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Target: WISP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E11
Application*: E, P, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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