XCR1

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

X-C Motif Chemokine Receptor 1

Function

Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.

Biological Process

Biological Process calcium-mediated signaling Source:GO_Central1 Publication
Biological Process cell chemotaxis Source:GO_Central1 Publication
Biological Process chemotaxis Source:ProtInc1 Publication
Biological Process G protein-coupled receptor signaling pathway Source:ProtInc1 Publication
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source:ProtInc1 Publication
Biological Process immune response Source:GO_Central1 Publication
Biological Process inflammatory response Source:ProtInc1 Publication
Biological Process positive regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Biological Process release of sequestered calcium ion into cytosol Source:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-31
Helical: 32-59
Cytoplasmic: 60-69
Helical: 70-89
Extracellular: 90-103
Helical: 104-125
Cytoplasmic: 126-142
Helical: 143-167
Extracellular: 168-190
Helical: 191-209
Cytoplasmic: 210-225
Helical: 226-250
Extracellular: 251-267
Helical: 268-291
Cytoplasmic: 292-333