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Rabbit Anti-XCR1 Recombinant Antibody (1097A) (CBMAB-X0115-YC)

Provided herein is a Rabbit monoclonal antibody against Human XCR1. The antibody, clone 1097A, can be used for immunoassay techniques, such as FC.
See all XCR1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
1097A
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
E. coli-derived recombinant human XCR1, Met1-Thr31, Ser89-Lys103, His168-His190, Phe251-Tyr267, Accession # P46094
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
X-C Motif Chemokine Receptor 1
Introduction
XCR1 is a chemokine receptor belonging to the G protein-coupled receptor superfamily. XCR1 is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. XCR1 transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling.
Entrez Gene ID
2829
UniProt ID
P46094
Alternative Names
GPR5; CCXCR1
Function
Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.
Biological Process
Biological Process calcium-mediated signaling Source:GO_Central1 Publication
Biological Process cell chemotaxis Source:GO_Central1 Publication
Biological Process chemotaxis Source:ProtInc1 Publication
Biological Process G protein-coupled receptor signaling pathway Source:ProtInc1 Publication
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source:ProtInc1 Publication
Biological Process immune response Source:GO_Central1 Publication
Biological Process inflammatory response Source:ProtInc1 Publication
Biological Process positive regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Biological Process release of sequestered calcium ion into cytosol Source:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-31
Helical: 32-59
Cytoplasmic: 60-69
Helical: 70-89
Extracellular: 90-103
Helical: 104-125
Cytoplasmic: 126-142
Helical: 143-167
Extracellular: 168-190
Helical: 191-209
Cytoplasmic: 210-225
Helical: 226-250
Extracellular: 251-267
Helical: 268-291
Cytoplasmic: 292-333
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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