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Rabbit Anti-XCR1 Recombinant Antibody (D2F8T) (CBMAB-CP3027-LY)

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Basic Information

Host Animal
Rabbit
Clone
D2F8T
Application
WB, IHC, IHC-P
Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human XCR1 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.56 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
X-C Motif Chemokine Receptor 1
Introduction
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
2829
UniProt ID
P46094
Function
Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.
Biological Process
Biological Process calcium-mediated signaling Source:GO_Central1 Publication
Biological Process cell chemotaxis Source:GO_Central1 Publication
Biological Process chemotaxis Source:ProtInc1 Publication
Biological Process G protein-coupled receptor signaling pathway Source:ProtInc1 Publication
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source:ProtInc1 Publication
Biological Process immune response Source:GO_Central1 Publication
Biological Process inflammatory response Source:ProtInc1 Publication
Biological Process positive regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Biological Process release of sequestered calcium ion into cytosol Source:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-31
Helical: 32-59
Cytoplasmic: 60-69
Helical: 70-89
Extracellular: 90-103
Helical: 104-125
Cytoplasmic: 126-142
Helical: 143-167
Extracellular: 168-190
Helical: 191-209
Cytoplasmic: 210-225
Helical: 226-250
Extracellular: 251-267
Helical: 268-291
Cytoplasmic: 292-333
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rabbit Anti-XCR1 Recombinant Antibody (1097A) (CAT#: CBMAB-X0115-YC)

Mouse Anti-XCR1 Recombinant Antibody (ZET) (CAT#: CBMAB-X0113-YC)

Human Anti-XCR1 Recombinant Antibody (REA707) (CAT#: CBMAB-X0112-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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