YBX2

This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15.

Full Name

YBX2

Function

Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity).

Biological Process

Biological Process oocyte development Source:Ensembl
Biological Process positive regulation of cold-induced thermogenesis Source:YuBioLabBy Similarity
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process spermatogenesis Source:ProtInc1 Publication
Biological Process transcription by RNA polymerase II Source:ProtInc1 Publication
Biological Process translational attenuation Source:ProtInc1 Publication

Cellular Location

Cytoplasm
Nucleus

PTM

Phosphorylated during oocyte maturation and dephosphorylated following egg activation. Phosphorylated in vitro by a kinase activity associated with testicular mRNPs. Dephosphorylation leads to a decrease in its affinity to bind RNA in vitro (By similarity).